The Schiff base, 2-[(2,3-dihydro-1H-inden-4-ylimino)methyl]-5-nitrophenol coordinates to Mn(II), Cu(II), Zn(II), and Pd(II)\nions through the phenolic O and imine N atoms. The complexes are characterized by physicochemical and spectroscopic methods.\nThe metal complexes formed as [ML2]xH2O with exception of the Cu(II) complex which is anhydrous. Spectroscopic data\ncorroborate the adoption of a four-coordinate, tetrahedral geometry for theMn(II), and Zn(II) complexes, and a four-coordinate,\nsquare planar geometry for the Cu(II) and Pd(II) complexes. None is an electrolyte in DMSO. The in vitro anticancer activities\nof the metal free ligand, Cu(II), Zn(II), and Pd(II) complexes against MCF-7 (human breast adenocarcinoma) and HT-29 (colon\ncarcinoma) cells reveal that the Pd(II) complex has the best cytotoxic activity against MCF-7 cells with an IC50 of 5.94 Ã?µM, which\nis within the same order of activity as cisplatin. Furthermore, the ligand and the Zn(II) complex exhibit broad-spectrum activity\nagainst two gram-positive bacteria, three gram-negative bacteria, and a fungus with inhibitory zones range of 10.0ââ?¬â??20.0 and 10.0ââ?¬â??\n17.0 mm, respectively.
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